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Harrison's Principles of Internal Medicine, Twenty-Second Edition is the world's most renowned and authoritative medical reference — the gold standard resource for internal medicine, clinical medicine, and physician education for more than seven decades. A Doody's Core Title for 2026 and #1 Bestseller in Diseases, this landmark two-volume set from McGraw Hill Medical provides the informational foundation healthcare professionals need to provide optimal patient care across all of internal medicine.
The 22nd Edition has been extensively modified in structure and content to reflect the latest guidelines, recommendations, and advances across the full span of medicine. Updated by the world's leading authority on applied pathophysiology and clinical medicine, Harrison's remains the definitive reference covering countless advances in biomedical science, diagnostics, therapeutics, and clinical practice — essential reading for physicians, residents, medical students, and advanced practice providers.
Fully updated with the most current evidence-based clinical content, the 22nd Edition serves as the essential companion for USMLE Step 1, Step 2, and Step 3 preparation, internal medicine board certification, and ABIM recertification. Lead authors include Dan Longo, Anthony S. Fauci, Dennis L. Kasper, Stephen Hauser, J. Larry Jameson, and Joseph Loscalzo — the foremost names in internal medicine and biomedical science.
Key areas covered include: infectious disease, cardiology, pulmonology, gastroenterology, nephrology, endocrinology, hematology and oncology, rheumatology, neurology, and clinical pharmacology — spanning the complete breadth of internal medicine practice. The indispensable two-volume reference for every physician and advanced healthcare provider.
